Abstract The ADP-ribosyltransferase, PARP1 enzymatically generates and applies the post-translational modification, ADP-Ribose (ADPR).PARP1 roles in genome maintenance are well described, but recent work highlights roles in many fundamental processes including cellular identity and energy homeostasis.Herein, we show in both mouse and human skeletal
It is widely recognized in science, policy, and practice that protected areas (PAs) that are equitably and effectively managed are essential for halting biodiversity loss.However, our understanding of the relationships between management effectiveness and equity remains weak.Here, we investigate potential synergies and trade-offs between management
The current outbreak of severe acute respiratory distress syndrome (SARS) or nCOVID-19 pandemic, caused by the PS-100 coronavirus-2 (CoV-2), continues to wreak havoc globally.As novel vaccines are being discovered and developed, small molecule drugs still constitute a viable treatment option for SARS-CoV-2 infections due to their advantages such as